Immunisation of cattle in Zimbabwe using Theileria parva (Boleni) without concurrent tetracycline therapy. uri icon


  • Five hundred and ten cattle were immunised using the Theileria parva (Boleni) stock without concurrent chemotherapy with tetracycline on 2 farms in Zimbabwe, both of which had a history of theileriosis. The stabilate had been titrated in Friesian calves to determine a 50% protective dose (PD50) and 2 or 3 (PD50s) were used to immunise the cattle.
  • Immunisation against theileriosis without the need for concurrent chemotherapy is much less expensive than the infection and treatment method (US$2.72) compared to US$10.23 in the first year) and would be much more attractive to commercial and traditional farmers.
  • None of the cattle showed a clinical reaction following the immunisation procedure. However, the cattle were shown to have responded immunologically on testing for antibodies to a T. parva antigen in an indirect fluorescent antibody test. The immunised cattle were then exposed to a natural field challenge causing severe theileriosis in control cattle.

publication date

  • 1997
  • 1997