Compositions and melanogenesis-inhibitory activities of the extracts of defatted shea (Vitellaria paradoxa) kernels from seven African countries uri icon

abstract

  • a Constituents of shea (Vitellaria paradoxa; Sapotaceae) kernels are commonly used as functional food and for skin care by indigenous peoples in Africa. Twenty-six MeOH extract samples of defatted shea kernels from seven subSaharan countries, Le., Cote d'Ivoire, Ghana, Nigeria, Cameroon, Chad, Sudan, and Uganda, were investigated in this study. HPLC coupled to an evaporative light -scattering detector and LC-QTOF (time -of -flight) -MS revealed that the extracts contained sugars (25.6-80.2%) as the most predominant constituents, followed by oleananetype triterpene glycosides (4.9-35.2%), accompanied by minor amounts of cucurbates (1.0-21.0%) and phenolic compounds (0.3-16.0%). Principal component analysis and hierarchical clustering analysis classified the twentysix samples into three groups. Upon evaluation of the melanogenesis-inhibitory activities of all samples in B16 melanoma cells induced by a-melanocyte-stimulating hormone, it was found that samples S2, S3, and S21 were lower -risk melanogenesis inhibitors (39.4-42.5% melanin content, 78.6-91.6% cell viability) with a small activity-to-cytotoxicity ratio (0.18-0.94), and were superior to reference arbutin at a concentration of 100 g/mL. These results suggest that the extracts of defatted shea kernels and their constituents can be regarded as skin whitening agents.

publication date

  • 2018
  • 2018