Musoke, A.J. Person

selected publications

• article

  • Extensive polymorphism of Ra86 genes in field populations of Rhipicephalus appendiculatus from Kenya..  Ticks and Tick-borne Diseases.  7:772-781. 2016
  • The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes.  INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE.  4:333-342. 2015
  • Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes.  Infection and Immunity.  82:1786-1792. 2014
  • Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity..  PLOS ONE.  6. 2011
  • Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus (Acari: Ixodida).  Insect Molecular Biology.  20:105-114. 2011
  • Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus..  Vaccine.  25:1287-1296. 2007
  • Approaches to improved understanding of vector parasite interaction within the genus Theileria and their Ixodid tick vectors 2007
  • Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ.  Experimental Parasitology.  114:271-278. 2006
  • Vaccines against Theileria parva..  Annals of the New York Academy of Sciences.  916:464-473. 2006
  • Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge.  Vaccine.  23:3084-3095. 2005
  • Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle.  Vaccine.  23:2791-2800. 2005
  • Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi..  Experimental Parasitology.  108:134-141. 2004
  • Monoclonal antibodies identify two neutralization-sensitive epitopes in Besnoitia besnoiti endocytes..  Parasitology Research.  94:247-253. 2004
  • Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens.  Veterinary Parasitology.  121:53-64. 2004
  • Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen..  Infection and Immunity.  72:2738-2741. 2004
  • Confirmation and dissection of QTL controlling resistance to malaria in mice..  Mammalian Genome.  15:390-398. 2004
  • Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses..  Infection and Immunity.  71:6906-6914. 2003
  • Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites..  Vaccine.  21:1205-1212. 2003
  • Baculovirus surface display of Theileria parva p67 antigen preserves the conformation of sporozoite-neutralizing epitopes.  PROTEIN ENGINEERING.  16:73-78. 2003
  • Quantitative analysis of dose-response effects in the transmission dynamics of Theileria parva and the impact of sporozoite-neutralising vaccines 2003
  • A cement protein of the tick Rhipicephalus appendiculatus, located in the secretory e cell granules of the type III salivary gland acini, induces strong antibody responses in cattle..  International Journal for Parasitology.  32:833-842. 2002
  • Fusion to green fluorescent protein improves expression levels of Theileria parva sporozoite surface antigen p67 in insect cells..  Parasitology.  125:497-505. 2002
  • Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targetting the disease rather than the parasite.  International Journal for Parasitology.  31:1429-1433. 2001
  • Monoclonal Antibody Binding to a Surface-Exposed Epitope on Cowdria ruminantium That Is Conserved among Eight Strains.  CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY.  7:983-986. 2000
  • Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres..  Molecular and Biochemical Parasitology.  110:359-371. 2000
  • A 32 kDa surface antigen of Theileria parva : characterization and immunization studies.  Parasitology.  120:553-564. 2000
  • Cloning, Characterization, and Expression of a 200-Kilodalton Diagnostic Antigen of Babesia bigemina.  Journal of Clinical Microbiology.  38:2240-2247. 2000
  • Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva..  Parasite Immunology.  22:223-230. 2000
  • Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen..  Molecular and Biochemical Parasitology.  107:309-314. 2000
  • A statistically derived index for classifying East Coast fever reactions in cattle challenged with Theileria parva under experimental conditions..  Parasitology.  120:371-381. 2000
  • Vaccines against Theileria parva.  Annals of the New York Academy of Sciences.  916:464-473. 2000
  • Enzymes of glucose and glycerol catabolism in in-vitro-propagated Theileria parva schizonts..  Veterinary Journal.  158:221-227. 1999
  • Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa..  Parassitologia.  73-80. 1999
  • Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems..  Tropical Medicine & International Health.  4:A71-A77. 1999
  • A Rab1 homologue with a novel isoprenylation signal provides insight into the secretory pathway of Theileria parva..  Molecular and Biochemical Parasitology.  102:131-143. 1999
  • Protective Immune Mechanisms against Theileria parva: Evolution of Vaccine Development Strategies.  Parasitology Today.  15:263-267. 1999
  • Molecular Characterization of a Haemaphysalis longicornis Tick Salivary Gland-Associated 29-Kilodalton Protein and Its Effect as a Vaccine against Tick Infestation in Rabbits.  Infection and Immunity.  67:1652-1658. 1999
  • Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralizing epitopes: implications for a vaccine..  Infection and Immunity.  67:1261-1266. 1999
  • Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa 1999
  • Molecular characterization of Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits 1999
  • Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM).  Parasitology.  117:321-330. 1998
  • Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection.  Vaccine.  16:1276-1282. 1998
  • Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites..  European Journal of Cell Biology.  76:125-132. 1998
  • Delivery of the p67 Sporozoite Antigen of Theileria parva by Using Recombinant Salmonella dublin: Secretion of the Product Enhances Specific Antibody Responses in Cattle.  Infection and Immunity.  66:2060-2064. 1998
  • Different vaccine strategies used to protect against Theileria annulata.  Annals of the New York Academy of Sciences.  849:234-246. 1998
  • Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva.  Vaccine.  16:834-841. 1998
  • Subunit vaccines for the control of tick-borne diseases: implications for the future..  Parassitologia.  39:131-137. 1997
  • Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan Theileria parva..  Molecular and Biochemical Parasitology.  85:265-269. 1997
  • Concerted evolution at a multicopy locus in the protozoan parasite Theileria parva: extreme divergence of potential protein-coding sequences..  Molecular and Cellular Biology.  17:1666-1673. 1997
  • Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles..  Infection and Immunity.  64:2056-2061. 1996
  • Conservation of Neutralizing Determinants between the Sporozoite Surface Antigens of Theileria annulata and Theileria parva.  Experimental Parasitology.  82:229-241. 1996
  • Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle 1995
  • Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva 1995
  • MHC class I molecules are an essential cell surface component involved in Theileria parva sporozoite binding to bovine lymphocytes 1995
  • MONOCLONAL-ANTIBODY TO A CONSERVED EPITOPE ON PROTEINS ENCODED BY BABESIA-BIGEMINA AND PRESENT ON THE SURFACE OF INTACT INFECTED ERYTHROCYTES.  Infection and Immunity.  63:3507-3513. 1995
  • Differences between N'Dama and Boran cattle in the ability of their peripheral blood leucocytes to bind antibody-coated trypanosomes 1991
  • The entry of Theileria parva sporozoites into bovine lymphocytes: Evidence for MHC class I involvement 1991
  • Identification of a Theileria mutans-specific antigen for use in an antibody and antigen detection ELISA 1990
  • Identification of lambda/gt11 clones encoding the major antigenic determinants expressed by Theileria parva sporozoites 1990
  • Recognition of Theileria parva antigens by field sera from Rusinga Island Kenya 1988
  • Comparison between bloodstream and procyclic form trypanosomes for serological diagnosis of African human trypanosomiasis 1987
  • Monoclonal antibodies that distinguish Trypanosoma congolense, T. vivax and T. brucei 1987
  • Immune effector mechanisms involved in the control of parasitaemia in Trypanosoma brucei-infected wildebeest (Connochaetes taurinus) 1986
  • Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and Trypanosoma brucei brucei infections 1984
  • Resistance of cattle to tsetse-transmitted challenge with Trypanosoma brucei or Trypanosoma congolense after spontaneous recovery from syringe-passaged infections 1984
  • Immune depression in bovine trypanosomiasis. Effects of acute and chronic Trypanosoma congolense and chronic Trypanosoma vivax infections on antibody response to Brucella abortus vaccine 1983
  • Bovine immune response to Theileria parva: Neutralizing antibodies to sporozoites 1982
  • Immunization trials against trypanosomiasis using common antigens 1982
  • Biological activities of bovine IgG subclasses 1981
  • Bovine immune response to African trypanosomes: specific antibodies to variable surface glycoproteins of Trypanosoma brucei 1981
  • Isotypic surface glycoproteins of trypanosomes 1981
  • Evidence for re-appearance of Trypanosoma brucei variant antigen types in relapse populations 1979
  • Immune response of the bovine to Trypanosoma brucei 1979
  • Isolation of a variant antigen fragment containing cross-reacting determinants from Trypanosoma brucei 1979
  • The radioimmunoassay in analysis of trypanosome cell surface structure 1979
  • Activation of complement by variant-specific surface antigen of Trypanosoma brucei 1977

• document

  • Immunological control of ticks: Research towards development of an anti-tick vaccine for cattle 2010
  • Theileria: Life cycle stages associated with the ixodid tick vector 2008
  • Monoclonal antibody binding to a surface exposed epitope on Cowdria ruminantium that is conserved among light strains 2000
  • Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine 1999
  • Preliminary observations on the development of a latex, slide agglutination test and its use for serodiagnosis of heartwater (Cowdria ruminantium infection) in small ruminants 1998
  • Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles 1996
  • Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva 1996
  • Sequence and expression of a 90-kilodalton heat-shock protein family member of Theileria parva 1994
  • A Sporozoite-based vaccine for Theileria parva 1993
  • Prospects for improved control of tick-borne diseases in Africa 1993
  • Variations in prevalence rates of tick-borne diseases in Zebu cattle by agroecological zone: implications for East Coast fever immunization 1993
  • Characterisation of the gene encoding a candidate vaccine antigen of Theileria parva sporozoites 1992
  • Prospects of improved control of tick-borne diseases in Africa 1992
  • Clone-specific immune colostrum induces increased resistance in goat kids challenged with Trypanosoma congolense 1991
  • A single exon codes for the enzyme domain of a protozoan cysteine protease 1990
  • Characterisation of the gene encoding a 104-kilodalton micronemerhoptry protein of Theileria parva 1990
  • Failure of trypanosomal membrane antigens to induce protection against tsetse-transmitted Trypanosoma vivax or Trypanosoma brucei in goats and rabbits 1984
  • Analysis of the variable antigen composition of Trypanosoma brucei metacyclic trypanosomes using monoclonal antibodies 1983
  • Complement activation and fibrinolysis during infection with (East Coast fever) in cattle 1983
  • Phagocytosis of antibody-sensitized Trypanosoma brucei in vitro by bovine peripheral blood monocytes 1983
  • Immune depression in African trypanosomiasis. The role of antigenic competition 1982
  • The bovine lymphoid system. 3. A monoclonal antibody specific for bovine cell surface and serum IgM 1980

• review

  • Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks.  Parasitology. S271-S283. 2004
  • Prospects for subunit vaccines against tick-borne diseases..  British Veterinary Journal. 621-639. 1996