Optimal allocation of patients in titration to fixed dose trials uri icon

abstract

  • Optimal allocations of patients to different arms of a fixed dose titration trial for estimating the dose-response relationship are provided. Optimal sample sizes are derived for the case where the linearizing transformation is log(dose). Optimal sample sizes for predicting the response are also derived. For equi-spaced dose levels on the log scale, the determination of optimal doses is also considered. (C) 2002 Elsevier Science B.V. All rights reserved.

publication date

  • 2002
  • 2002