Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution.
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We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215 000 MW WCl antigen and is negative for the cell-surface differentiation antigens CD2, CD4, and CD8. The second population expresses CD2 and CD8 but not WCl and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WCl+ population. The WCl- population is found in large numbers in spleen and intestine. In addition, this subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WCl+ population. The results indicate that the gamma delta T-cell. population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution.
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