epitope Concept

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Overview

research area of

• Awino, Elias, Research Officer, ILRI, ILRI
• Nene, Vish, Co-Leader, Animal and Human Health, ILRI, ILRI
• Osaso, Julius, Research Officer - Diagnotics Platform, ILRI, ILRI
• Pelle, Roger, Principal Scientist - Molecular Parasitologist, ILRI, ILRI
• Saya, Rosemary, Research Officer, ILRI, ILRI
• Steinaa, Lucilla, Principal Scientist - Cellular Immunologist, ILRI, ILRI
• Svitek, Nicholas, Senior Scientist - Cellular Immunologist, ILRI, ILRI

subject area of

• **Trypanosoma evansi**: cloning and expression in **Spodoptera fugiperda** insect cells of the diagnostic antigen RoTat1.2
• A mutation in Transportin3 (Tnpo3) leads to generation of an individually distinct tumor-specific Kd-restricted epitope in the Meth A fibrosarcoma (TUM2P.899)
• Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa.
• BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva.
• CD8 T-cell responses against the immunodominant Theileria parva peptide Tp249-59 are composed of two distinct populations specific for overlapping 11-mer and 10-mer epitopes.
• CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity.
• Camelid nanobodies with high affinity for broad bean mottle virus: a possible promising tool to immunomodulate plant resistance against viruses
• Characterisation of a monoclonal antibody recognising the CD3ε chain of the bovine T cell receptor complex
• Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery
• Characterization of the Fine Specificity of Bovine CD8 T-Cell Responses to Defined Antigens from the Protozoan Parasite Theileria parva
• Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)
• Cloning, Characterization, and Expression of a 200-Kilodalton Diagnostic Antigen of Babesia bigemina
• Conservation of Neutralizing Determinants between the Sporozoite Surface Antigens of Theileria annulata and Theileria parva
• Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen.
• Designing bovine T cell vaccines via reverse immunology.
• Differential T‐cell responses to a chimeric Plasmodium falciparum antigen; UB05‐09, correlates with acquired immunity to malaria
• Escape from CD8+ T Cell Response by Natural Variants of an Immunodominant Epitope from Theileria parva Is Predominantly Due to Loss of TCR Recognition
• Expression of RoTat 1.2 cross-reactive variable antigen type in Trypanosoma evansi and T. equiperdum
• Extensive Polymorphism and Evidence of Immune Selection in a Highly Dominant Antigen Recognized by Bovine CD8 T Cells Specific for Theileria annulata
• Genes encoding two Theileria parva antigens recognized by CD8+ T-cells exhibit sequence diversity in South Sudanese cattle populations but the majority of alleles are similar to the Muguga component of the live vaccine cocktail.
• Homodimeric alkaline phosphatase located at Helicoverpa armigera Midgut, a putat ive receptor of Cry1Ac contains α-GaINAc in term inal glycan structure as interactive Epitope
• Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
• Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites.
• Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralizing epitopes: implications for a vaccine.
• Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva
• Monoclonal Antibody Binding to a Surface-Exposed Epitope on Cowdria ruminantium That Is Conserved among Eight Strains
• Monoclonal antibodies identify two neutralization-sensitive epitopes in Besnoitia besnoiti endocytes.
• Post-translational signal peptide cleavage controls differential epitope recognition in the QP-rich domain of recombinant Theileria parva PIM.
• Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes
• Sequence-Based Genotyping of Expressed Swine Leukocyte Antigen Class I Alleles by Next-Generation Sequencing Reveal Novel Swine Leukocyte Antigen Class I Haplotypes and Alleles in Belgian, Danish, and Kenyan Fattening Pigs and Göttingen Minipigs.
• T cell epitope identification for bovine vaccines: an epitope mapping method for BoLA A-11
• The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality
• The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance.
• Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines.
• Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity.
• Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle
• Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus.
• Whole Genome Sequence Analysis of Porcine Astroviruses Reveals Novel Genetically Diverse Strains Circulating in East African Smallholder Pig Farms