antigen Concept

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research area of

• Awino, Elias, Research Officer, ILRI, ILRI
• Githaka, Naftaly, Scientist - Tick Biology and Vaccines & Tick Unit Manager, ILRI, ILRI
• Ndiwa, Nicholas, Database Manager & Analyst, ILRI, ILRI
• Nene, Vish, Co-Leader, Animal and Human Health, ILRI, ILRI
• Njoroge, Thomas, Research Associate, ILRI, ILRI
• Osaso, Julius, Research Officer - Diagnotics Platform, ILRI, ILRI
• Pelle, Roger, Principal Scientist - Molecular Parasitologist, ILRI, ILRI
• Poole, Jane, Consultant, ILRI, ICRAF
• Saya, Rosemary, Research Officer, ILRI, ILRI
• Schieck, Elise, Scientist - Mycoplasma, ILRI, ILRI
• Shah, Trushar, Integrated Breeding Platform (IBP) Hub Manager, IITA, CIMMYT
• Steinaa, Lucilla, Principal Scientist - Cellular Immunologist, ILRI, ILRI
• Svitek, Nicholas, Senior Scientist - Cellular Immunologist, ILRI, ILRI
• Taylor, Katarlah, Manager, Events, IFPRI, IFPRI

subject area of

• A 32 kDa surface antigen of Theileria parva : characterization and immunization studies
• A highly sensitive, non-radioactive assay for T cell activation in cattle: applications in screening for antigens recognised by CD4(+) and CD8(+) T cells
• A mutation in Transportin3 (Tnpo3) leads to generation of an individually distinct tumor-specific Kd-restricted epitope in the Meth A fibrosarcoma (TUM2P.899)
• A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology.
• A putative, novel coli surface antigen 8B (CS8B) of enterotoxigenic Escherichia coli.
• A subset of Cowdria ruminantium genes important for immune recognition and protection.
• An Ad/MVA vectored Theileria parva antigen induces schizont-specific CD8+ central memory T cells and confers partial protection against a lethal challenge.
• Analysis of monoclonal antibodies reactive with molecules upregulated or expressed only on activated lymphocytes
• Analysis of monoclonal antibodies specific for the gamma delta TcR.
• Analysis of the Role of TpUB05 Antigen from Theileria parva in Immune Responses to Malaria in Humans Compared to Its Homologue in Plasmodium falciparum the UB05 Antigen
• Analysis of the immunoproteome of Mycoplasma mycoides subsp. mycoides small colony type reveals immunogenic homologues to other known virulence traits in related Mycoplasma species.
• Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa.
• Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro.
• Antigenic similarity among Anabaena azollae separated from different species of Azolla.
• Antigens for an east coast fever vaccine
• Approaches to vaccination against Theileria parva and Theileria annulata.
• Assessment of in vitro interferon-γ responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type
• BIOCHEMICAL ANALYSIS OF PRELIMINARY CLUSTERS IN THE NON-LINEAGE PANEL
• Baseline analysis of Mycoplasma mycoides subsp. mycoides antigens as targets for a DIVA assay for use with a subunit vaccine for contagious bovine pleuropneumonia
• BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva.
• Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen.
• Bovine γδ T-Cell Responses to the Intracellular Protozoan Parasite Theileria parva
• CD5+ B lymphocytes are the main source of antibodies reactive with non‐parasite antigens in Trypanosoma congolense‐infected cattle
• CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity.
• Cellular immune responses of cattle to Cowdria ruminantium.
• Characterisation of a heparan sulfate proteoglycan homologue OvPG-1 from Onchocerca volvulus.
• Characterisation of a monoclonal antibody recognising the CD3ε chain of the bovine T cell receptor complex
• Characterisation of bovine transferrin receptor on normal activated and Theileria parva-transformed lymphocytes by a new monoclonal antibody.
• Characterization of Monoclonal Antibodies to the αIIbβ3 Integrin on Bovine Platelets
• Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery
• Characterization of the Fine Specificity of Bovine CD8 T-Cell Responses to Defined Antigens from the Protozoan Parasite Theileria parva
• Characterization of the Theileria parva sporozoite proteome
• Characterization of the in vitro core surface proteome of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious bovine pleuropneumonia §
• Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM)
• Cloning, Characterization, and Expression of a 200-Kilodalton Diagnostic Antigen of Babesia bigemina
• Comparative Transcriptomics of the Bovine Apicomplexan Parasite Theileria parva Developmental Stages Reveals Massive Gene Expression Variation and Potential Vaccine Antigens.
• Comparative analysis of adaptive immune responses following experimental infections of cattle with bovine viral diarrhoea virus-1 and an Asiatic atypical ruminant pestivirus.
• Comparative evaluation of novel African swine fever virus (ASF) antibody detection techniques derived from specific ASF viral genotypes with the OIE internationally prescribed serological tests.
• Conservation of Neutralizing Determinants between the Sporozoite Surface Antigens of Theileria annulata and Theileria parva
• Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles.
• Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen.
• Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
• Delivery of the p67 Sporozoite Antigen of Theileria parva by Using Recombinant Salmonella dublin: Secretion of the Product Enhances Specific Antibody Responses in Cattle
• Design and evaluation of the immunogenicity and efficacy of a biomimetic particulate formulation of viral antigens
• Designing bovine T cell vaccines via reverse immunology.
• Detection and differentiation between trypanosome species in experimentally infected tsetse flies (Glossina spp.) using dot-ELISA
• Differential T‐cell responses to a chimeric Plasmodium falciparum antigen; UB05‐09, correlates with acquired immunity to malaria
• Distinct CD4+ T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors.
• East coast fever vaccine based on ctl-specific schizont antigens
• Effect Of Different Prepared Antigens Of Pseudomonas fluorescens On Specific And Non-Specific Immune Response Of Nile tilapia (Oreochromis niloticus)
• Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies
• Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection.
• Evaluation of antigen detection and antibody detection tests for Trypanosoma evansi infections of buffaloes in Indonesia.
• Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems.
• Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle.
• Evidence for four functional DQA loci in cattle with distinct distributions amongst European and African populations
• Expression and characterization of Ov-47, a dominant antigen of Onchocerca volvulus.
• Expression of RoTat 1.2 cross-reactive variable antigen type in Trypanosoma evansi and T. equiperdum
• Extensive Polymorphism and Evidence of Immune Selection in a Highly Dominant Antigen Recognized by Bovine CD8 T Cells Specific for Theileria annulata
• First Report of the Occurrence of Trichinella-Specific Antibodies in Domestic Pigs in Central and Eastern Uganda.
• Functional expression of a bovine major histocompatibility complex class I gene in transgenic mice
• Fusion of a cell penetrating peptide from HIV-1 TAT to the Theileria parva antigen Tp2 enhances the stimulation of bovine CD8⁺ T cell responses
• Fusion to green fluorescent protein improves expression levels of Theileria parva sporozoite surface antigen p67 in insect cells.
• Genetic mapping of bovine T‐cell receptor complex loci
• Genome Sequence of Streptococcus agalactiae Strain 09mas018883, Isolated from a Swedish Cow.
• Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses.
• High antibody titres against predicted Mycoplasma surface proteins do not prevent sequestration in infected lung tissue in the course of experimental contagious bovine pleuropneumonia
• Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues.
• Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
• Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides.
• Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution.
• IgG antibodies from dourine infected horses identify a distinctive Trypanosoma equiperdum antigenic pattern of low molecular weight molecules.
• Immmunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes
• Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever.
• Immune response of cattle infected with african trypanosomes
• Immune responses of cattle to African trypanosomes: protective or pathogenic?
• Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent.
• Immunization of Cattle by Infection with Cowdria ruminantium Elicits T Lymphocytes That Recognize Autologous, Infected Endothelial Cells and Monocytes†
• Immunological Characterization and Expression in Escherichia coli and Baculovirus Systems of a Trypanosoma vivax Antigen Detected in the Blood of Infected Animals
• Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens
• In Silico Characterization and Structural Modeling of Dermacentor andersoni p36 Immunosuppressive Protein
• Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralizing epitopes: implications for a vaccine.
• Major Antigenic Proteins 1 and 2 of Cowdria ruminantium Are Targets for T-Lymphocyte Responses of Immune Cattlea
• Molecular and immunological characterisation of Theileria parva stocks which are components of the 'Muguga cocktail' used for vaccination against East Coast fever in cattle.
• Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen.
• Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen.
• Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva
• Monoclonal Antibody Binding to a Surface-Exposed Epitope on Cowdria ruminantium That Is Conserved among Eight Strains
• Monoclonal antibodies identify two neutralization-sensitive epitopes in Besnoitia besnoiti endocytes.
• Nomenclature and characterization of leukocyte differentiation antigens in ruminants.
• Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.
• Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type.
• Plasmodium falciparum variant erythrocyte surface antigens: a pilot study of antibody acquisition in recurrent natural infections.
• Probabilistic order in antigenic variation of Trypanosoma brucei.
• Prospects for subunit vaccines against tick-borne diseases.
• Purification and some serological relationships of tomato spotted wilt virus isolates occurring on peanut (Arachis hypogaea) in the USA
• Rapid changes occur in the percentage of circulating bovine WC1+γδ Th1 cells
• Rapid latex agglutination (RLA) test for the diagnosis of Babesia Argentina
• Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva.
• Recombinant Antigen Targets for Serodiagnosis of African Swine Fever
• Recombinant Mycoplasma mycoides proteins elicit protective immune responses against contagious bovine pleuropneumonia.
• Recombinant RoTat 1.2 variable surface glycoprotein as antigen for diagnosis of Trypanosoma evansi in dromedary camels.
• Rhipicephalus microplus cystatin as a potential cross-protective tick vaccine against Rhipicephalus appendiculatus.
• Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes
• Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypanosoma vivax infections in cattle.
• Serological relationships and purification of bud necrosis virus, a tospovirus occurring in peanut (Arachis hypogaea L.) in India
• Studies on a Nigerian isolate of banana streak badnavirus: I. Purification and enzyme linked immunosorbent assay
• Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
• Survey of maedi-visna (MV) in ethiopian highland sheep.
• Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
• T cell epitope identification for bovine vaccines: an epitope mapping method for BoLA A-11
• T-cell responses to Mycobacterium avium PPD antigens in gastro-intestinal helminth co-infected chickens in Central Ethiopia.
• The expression of RoTat 1.2 variable surface glycoprotein (VSG) in Trypanosoma evansi and T. equiperdum
• The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance.
• Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines.
• Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
• TpUB05, a Homologue of the Immunodominant Plasmodium falciparum Protein UB05, Is a Marker of Protective Immune Responses in Cattle Experimentally Vaccinated against East Coast Fever.
• Transcription of the unique ruminant class II major histocompatibility complex-DYA and DIB genes in dendritic cells.
• Transcriptomics reveal potential vaccine antigens and a drastic increase of upregulated genes during Theileria parva development from arthropod to bovine infective stages.
• Treatment of cattle with DNA-encoded Flt3L and GM-CSF prior to immunization with Theileria parva candidate vaccine antigens induces CD4 and CD8 T cell IFN-γ responses but not CTL responses.
• Trypanosoma congolense: a comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection.
• Trypanosoma congolense: tissue distribution of long-term T- and B-cell responses in cattle
• Trypanosoma congolense:B-Lymphocyte Responses Differ between Trypanotolerant and Trypanosusceptible Cattle
• Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive.
• Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity.
• Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells.
• Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle
• Vaccination of Cattle with the N Terminus of LppQ of Mycoplasma mycoides subsp. mycoides Results in Type III Immune Complex Disease upon Experimental Infection
• Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus.
• Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation.
• Vaccines against Theileria parva.
• Vaccines and diagnostic tools for animal health: the influence of biotechnology